Effects of Long-term Use of Depo-medroxyprogesterone Acetate on Lipid Metabolism in Nepalese Women
نویسندگان
چکیده
Various synthetic progestogens that are used as contraceptives have been reported to influence lipid and lipoprotein fractions differently. Depo-medroxyprogesterone acetate (DMPA), a synthetic progestogen, is used by Nepalese women as a contraceptive agent. Our study aims to determine the effects of long-term use of DMPA on lipid metabolism. We performed this study on 60 healthy Nepalese women who had been using DMPA for more than 2 yr and age- and weight-matched control subjects who were not using hormonal contraceptives. Fasting blood samples were collected from the subjects for the estimation of total cholesterol (TC) and triglyceride (TG) levels, and the levels of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were estimated using the Friedewald's equation. TC and LDL-C levels in DMPA users were significantly higher than those in non-users. Our study concluded that DMPA use induces lipid metabolism changes that can increase the risk of cardiovascular diseases.
منابع مشابه
Effect of medroxyprogesterone acetate on hepatic and placental drug metabolism in rats.
Medroxyprogesterone acetate (MPA: Depo-Provera) is a long-acting synthetic progestin that has been used as a contraceptive for more than 11 million women-years in 80 nations [1]. The U.S. Food and Drug Administration has denied approval of MPA as a contraceptive because of concern about its safety, especially teratogenicity and carcinogenicity [2.3]. In addition to its contraceptive action, MPA...
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